Endocrine Abstracts

Diabetes contributes to 80% mortality in coronary heart disease (CHD). Hyperglycaemia antedates diabetes and is a late stage in the series of events leading to diabetes.Stress hyperglycaemia on admission with acute myocardial infarction (AMI) has been reported to have an increased risk of in-hospital mortality/morbidity.We conducted a retrospective study of all AMI admissions to coronary care unit over a six-month period to see th...

Case history: A 46-year-old headmaster with a 10-year history of hypertension presented with a BP of 164/116 mmHg on four antihypertensive drugs. He had occasional headaches, chest ‘aches’, and described one syncopal episode after an ‘exhausting rowing session’. A low plasma renin (routinely measured in our resistant hypertensives) and 26/20 mmHg fall in BP on changing hydrochlorothiazide to amiloride, led to investigations for primary aldosteronism (PA).</...

Paraneoplastic Cushing's syndrome is a rare disease and is usually associated with small lung cancer or bronchial carcinoid tumour. In this case report we present an unusual case of metastatic neuroendocrine tumour of the pancreas presenting with florid Cushing's syndrome. A 45-year-old female presented with four-month history of worsening blurred vision, dry mouth and lethargy. In the hindsight, for the past three ...

Paraneoplastic Cushing's syndrome is a rare disease and is usually associated with small lung cancer or bronchial carcinoid tumour. In this case report we present an unusual case of metastatic neuroendocrine tumour of the pancreas presenting with florid Cushing's syndrome. A 45-year-old female presented with four-month history of worsening blurred vision, dry mouth and lethargy. In the hindsight, for the past three ...

Case history: A 38 years old Afro-Caribbean gentleman presented in June 2018 with symptoms of hyperthyroidism. He is a smoker and takes alcohol occasionally. Examination revealed fine tremors, tachycardia, moderate sized goitre with no thyroid bruit and right sided proptosis. Thyroid workup revealed suppressed TSH, raised free T4 and TRAb of 9.75 IU/L suggesting Graves’ Thyrotoxicosis. He was started on 20 mg of Carbimazole (CBZ)OD with Propanolol. After initiating carbim...

An 82 year old gentleman was admitted with lethargy, shortness of breath and weight loss of 26% total body weight over a two-year period. His past medical history included hypertension, pulmonary fibrosis, thalassaemia trait and unexplained thrombocytopenia.He had previously been investigated for weight loss with a CT thorax/abdomen/pelvis in 2014 which demonstrated no evidence of malignancy and FDG PET had shown no disease.On admi...

Introduction: Adrenal venous sampling (AVS) is the reference standard test to differentiate between unilateral and bilateral adrenal diseases in patients with primary hyperaldosteronism. Current Endocrine society guidelines recommend AVS in all cases of primary hyperaldosteronism where surgery is desirable and practical. However, this procedure is technically challenging and failure rate is high.Aims: The aim of this audit was to evaluate success rate of...

Erratic release of insulin accounts from periodic nature of the symptoms in insulinoma. Islet-amyloid polypeptide has been demonstrated in human insulin producing tumours- insulinoma. Presence of amyloid tissue has been demonstrated in pancreatic islets in patients with diabetes mellitus. Impaired islet function is a feature of diabetes mellitus. Hyperglycaemia, as in diabetes, enhances amylin secretion. Presence of insulinoma has been documented in past but insulionoma presen...

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Diabetes and impaired glucose tolerance are associated with increased risk of cardiovascular diseases. Criteria for high risk populations that should be screened for diabetes needs be revising.Hospital admissions are stressful events and abnormally high random blood glucose levels are not acted upon appropriately.We studied 100 consecutive admissions to coronary care unit to assess the incidence of hyperglycaemia/diabetes on admiss...